91制片厂 (UC) Business School lecturer听Dr Pan Zheng听is researching a novel way of speeding up the process using machine learning and AI (artificial intelligence) to assist drug repurposing.
鈥淚t costs millions of dollars to produce a new medicine, and takes a long time before it can be released to the public,鈥 he says. At a molecular level, the chemical structure in medicine reacts with the protein structure of a disease to suppress or stop it, providing a cure.
鈥淚鈥檓 studying the mapping from the chemical structure to the protein structure to construct a machine learning model that predicts the possible relations. In biochemistry term, it is called binding affinity. There are existing databases that keep such information. Machine learning models can be created and trained using these data sets. When there is a new protein structure, i.e., a disease, input to the model, it will recommend some existing medicines that could be possible cures.,鈥 Dr Pan says.
鈥淟ike all machine learning models, it won鈥檛 be 100%, but with continued improvement we鈥檒l be able to get to 80%, 90%, 95% accuracy.鈥
This approach to drug repurposing saves time and money, making it quicker and cheaper to make medicine publicly available as well as reducing the cost for the end user.
鈥淭he more information that goes into the model, the better the solutions it will present 鈥 quicker and more accurate.鈥
Dr Pan has been working on this research for a year with colleagues in China, Malaysia and Spain. From a computer science background, he joined the UC Business School鈥檚 Accounting and Information Systems department in 2018.
鈥淚 did study science, but business schools are so multidisciplinary. I鈥檓 working in information systems. It is a discipline that is 听always trying to help the management and operations of organisations work smarter and more efficiently,鈥
Another medical application for this research is to use machine learning and AI to test for Alzheimer鈥檚 disease, which is often done on paper with a doctor.
A bonus benefit is it could free up the doctor to see more patients, he says.
鈥淔rom an AI perspective, we are trying to liberate humans from tedious work by giving it to machines. With AI we are progressing society. For example, driverless cars could see taxi drivers lose their jobs, but new jobs are also created, too, like software engineers, system developers and programmers.鈥
Dr. Pan Zheng received the UC Business School New, Early and Emerging Career Research Award in 2020.
